Mangonelab

Genetics and Genomics in C. elegans

Welcome to the Mangone Lab @ Arizona State University

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Let's celebrate our successful Undergraduate students!

Mangonelab Undergraduate students

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Jillian Murray (Undergraduate Student) Barrett Honors College
Accepted in the Biology Graduate Program at Mitchigan University. Congratulations Jillian!
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RNA transcription has been studied for more than half a century, focusing mainly on the initiation and elongation processes.
We still do not understand, however, the mechanisms of transcriptional termination, preparation of 3' mRNA ends, or the regulation of these sequences that, in turn, control gene expression at a post-transcriptional level.
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The mRNA molecule is the key intermediate of this process.
RNA is a perfect copy of the information contained in DNA, and instructs its temporal and spatial expression – producing proteins, shaping organs, timing development, and regulating biological processes in living organisms.
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Understanding how RNA transcription termination works in living organisms is very important because it will help to understand what happens in disease states such as cancer, Alzheimer’s, autism, and muscular dystrophy, all disease where this process is disrupted.
Without a deep understanding of these and other basic biological processes, our approach to human health is limited.
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The long-term goal of our laboratory is to highlight the fundamental biological mechanisms that control RNA transcription termination using a systems biology approach, taking advantage of biochemistry, high-throughput genomics, and the powerful genetics provided by the roundworm C. elegans and human cell lines.


News

emma
5/3/2024
Emma Murari received the SoLS Thesis Completion Fellowship. Contratulation Emma!


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7/28/2023
Dalton Meadows (Grad Student) won the Best Poster Award (First Place) in the Gene Regulation and Genomics section at the International Worm Meeting In Glasgow. Congratulation Dalton !!!!!!

Marco Mangone, Biodesign institute at Arizona State University, 727 E. Tyler St. Tempe, AZ 85287